Misregulation of synaptic function results in abnormal brain function and behavior that is manifested in numerous neurological and psychiatric diseases. This course will explore the molecular mechanisms responsible for altered synaptic plasticity in neurological diseases such as frontotemporal dementia (FTD), Parkinson's disease, Huntington's disease, Creutzfeldt-Jakob disease, Down syndrome, epilepsy, autism, and Alzheimer's disease. Recommended prereqs., MCDB 3650 or NRSC 2100 (minimum grade C-) or instructor consent required.
Investigate the inner workings of our cells by studying how poisons disrupt these processes. We will learn how selected poisons affect critical processes inside the cell to cause death or destruction. The scientific aspects of the poison will be discussed in the context of its historical significance or impact on society and popular culture. Prereqs., MCDB 1150 or EBIO 1210 and MCDB 2150.
Introduces majors with relatively little mathematical experience to the major concepts in systems biology, in the context of key processes (cell growth, division, adaptation, development, and disease). Course is designed to help students master the necessary mathematical tools involved. Recommended prereqs., MCDB 3135 and MATH 1310 (minimum grade C-).
Learning molecular and cell biology experimental design and approaches through independent research projects. Students, working in pairs, will explore the research process and gain extensive first-hand experience in: hypothesis formation; experimental design; solution preparation and experimental methodology; proposal presentation and defense (oral and written); formal presentation of results and conclusions (oral and written in a publication-style format); the publication process; critical reading and evaluation of primary scientific literature. Recommended prereqs., MCDB 1150 or EBIO 1210 (minimum grade C-). Recommended coreq., MCDB 3135.
Demonstrates the breadth of research in the life sciences and how such research (not just in medical schools) can lead to medical applications. Lecturers from life sciences, the medical school and biotechnology, discuss drug development and the transfer of research into the clinical arena. Students also prepare a paper and presentation on the development of a commercial drug. Recommended prereqs., MCDB 3135 and MCDB 3145 (minimum grade C-).
Studies how python hearts grow after they consume a meal. Understanding the molecular processes of growth and regression in the python heart could lead to development of therapeutics for heart disease. Students work in groups in the laboratory and generate novel data by using modern molecular biology and bioinformatic techniques to clone and sequence candidate molecules of the python genome. May be repeated once. Recommended prereqs., MCDB 3135 and MCDB 3145 (minimum grade C-).
Presents a rigorous and pedagogically coherent introduction into the experimental process used to collect data, formulate hypotheses, and answer scientific questions in general, and biological questions in particular. Includes a detailed consideration of the elements of experimental design, data collection and analysis, and the interpretation of results in the context of effective science teaching. Part of the CU Teach course sequence for teacher certification in science and mathematics. Recommended prereqs., MCDB 3135 and MCDB 3145 (minimum grade C-). Requisites: Restricted to Biological Sciences (MCDB) majors or School of Education (EDUC) undergraduate students only.
Emphasizes cellular and molecular mechanisms by which organisms protect themselves from pathogens and the experimental basis for our understanding of these processes. Discusses development, function, and misfunction of t-cells, b-cells and other components of the immune system, focusing on the human immune system. Recommended prereqs., MCDB 3135 and MCDB 3145 (minimum grade C-). Same as MCDB 5301.
Examines the physiology and genetics of bacteria, Archaea and viruses. Particular emphasis will be on metabolism, regulation of gene expression and protein function, mechanisms of interactions with and manipulation of the environment, and evolution in response to environmental pressures. Recommended prereqs., MCDB 3135 and MCDB 3145 (minimum grade C-). Recommended coreq., CHEM 4611. Same as MCDB 5310.
Surveys combinatorial algorithms used to understand DNA, RNA, and proteins. Introduces students to methods used to process genomic data. Topics covered include a review of algorithms and molecular biology, sequence analysis, RNA and protein structure analysis, and comparative genomics. Students will get hands-on experience processing recent genomic data. Recommended prereqs., CSCI 2270 and CSCI 3104 or CHEM 4711 or MCDB 3135 or IPHY 4200 (minimum grade C-). Same as CSCI 4314 and MCDB 5314.
Explores molecular and cellular interactions between bacteria and their eukaryotic hosts that precipitate disease. Activities include critical reading of review and research articles, preparation of homework assignments based on readings, and student presentations of assigned papers. Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 2150 or MCDB 3135 and MCDB 3145 (minimum grade C-). Same as MCDB 5330.
Provides a molecular phylogeny-based perspective on microbial diversity and the interactions between organisms that result in the biosphere. Provides overview of recent methods and findings in microbial ecology, as well as computer-based workshop in molecular phylogeny. Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 1150 or EBIO 1210 and CHEM 1133 or CHEM 1371 and EBIO 3400 and/or CHEM 3311 (minimum grade C-). Same as MCDB 5350.
Relates how recent discoveries in the molecular mechanisms of development are shaping our understanding of animal evolution. The course will review basic principles of molecular developmental biology and apply these concepts to critically discuss current research in the field of Evo-Devo (evolution and development). Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 3135 and MCDB 3145 (minimum grade C-). Same as MCDB 5361.
Studies the human organism as a genetic system, including effect of mutation on protein structure and function, biochemical basis of human genetic disease, polymorphic gene loci, gene mapping and identification, gene cloning and characterization, and impact of human genetics on medicine and society. Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 3135 (minimum grade C-).
Examines how free radicals are formed in biological systems and their roles in oxidative stress, cell signalling, aging, and disease. Emphasis will be placed on the recent literature. Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 3135, MCDB 3145 and CHEM 3311 (minimum grade C-).
In this critical thinking course, students will apply their knowledge of basic biology to exploring several of the most exciting topics in biomedicine including protein folding and stress responses, nutrient sensing and balance, and signal transduction across membranes. Emphasis will be placed upon human physiology and associated human diseases including Alzheimer's disease, diabetes, and cardiovascular disease. Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 3135 and MCDB 3145 (minimum grade C-) or instructor consent required. MCDB 4425 and 5425 are the same course.
Introduces several cell signaling processes and their biological functions. Students read and analyze original research articles to learn the thinking processes of scientific research. Writing assignments and oral presentations are required. Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 3135, MCDB 3145 and CHEM 4771 (minimum grade C-). Same as MCDB 5426.
Explores the neurobiology, cell biology, genetics and developmental biology of the visual system. Discusses neurodegenerative and vascular diseases that lead to blindness. Students read and analyze original research articles to train scientific reasoning. Involves student-organized presentations and classroom discussion. Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 3135 and MCDB 3145 (minimum grade C-) or instructor consent required. Same as MCDB 5427.
Surveys development in a range of vertebrate and invertebrate systems to reconstruct the common bilatorian ancestor, and elucidate the developmental genetic changes underlying animal diversification. Lab focuses on vertebrate embryos and explores key methods in evolutionary developmental biology including in situ hybridization, embryo microinjection, and transgenesis. Recommended prereqs., MCDB 1150 or EBIO 1210 and MCDB 2150 or EBIO 2070 (minimum grade C-). EBIO 4440, EBIO 5440, MCDB 4441, and MCDB 5441 are all the same course.
Focuses on manifestations of regulated gene expression. Studies gene regulation at multiple steps, including transcription, RNA processing, and translation. Is based on critical analysis of primary research papers. Written assignments and oral presentations are required. Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 3135 (minimum grade C-) or instructor consent required. Same as MCDB 5471. Credit not granted for this course and MCDB 4470/5470.
Computational and experimental methods in bioinformatics and genomics, and how these methods provide insights into protein structure and function, molecular evolution, biological diversity, cell biology, and human disease. Topics include database searching, multiple sequence alignment, molecular phylogeny, microarrays, proteomics, and pharmacogenomics. Recommended prereqs., MCDB 3135 or CHEM 4711 and CHEM 4731 (minimum grade C-). Same as MCDB 5520.
Focuses on the biophysics governing the structure/function of enzymes, cells, extra-cellar matrix, and tissue. Synthesizes ideas from molecular biology, physics, and biochemistry, emphasizing how low Reynolds number physics, not Newtonian physics, is relevant to life inside a cell. Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 3135 and 3145 and PHYS 2010 and 2020 and CHEM 1133 or 1371 and MATH 1300 and/or CHEM 3311 (minimum grade C-) or instructor consent required. Same as MCDB 5550.
Stem cells have received considerable notice in both the scientific and social arena. The course will examine the stem cell concept by a critical examination of the primary scientific literature. Topics will include pluripotency and plasticity, environment, technology, self-renewal, transdifferentiation, molecular signature, epigenetic programming and stem cell versus cancer cell. Fulfills MCDB scientific reasoning requirement. Recommended prereqs., MCDB 3135 or MCDB 3145 or instructor consent required. Same as MCDB 5615.
